By its Hidden GEMS Program and this science developed by the NIH, One Million Options in Well being presents the possibility to study licensing a revolutionary know-how that might considerably enhance survival charges for sure cancers.
BOSTON, Jan. 31, 2021 /PRNewswire-PRWeb/ — For this breakthrough science to deal with colon most cancers and glioblastoma, One Million Options in Well being through their Hidden GEMS Program partnered with the USA’ Nationwide Institutes of Well being Workplace of Expertise Switch (NIH-OTT) and the Nationwide Most cancers Institute Expertise Switch Middle (NCI-TTC) to unfold consciousness of NIH applied sciences and advances, to commercialize this new science by means of licensing agreements.
Dr. Zhengping Zhuang and Dr. Herui Wang share their work on this scientific presentation and licensing alternative assessment which is spearheaded by One Million Solutions in Health. Throughout this presentation which is entitled “NIH Licensing Alternative: Breakthrough Science to Deal with Colon Most cancers and Glioblastoma” scientific scouts, enterprise leaders and commercialization consultants are supplied with the chance to amass information concerning the newest science and know-how straight from these NIH scientists.
On this scientific and alternative presentation, these attendees with robust information about this market and the scientific want for brand new know-how can even participate in One Million Options in Well being’s unique Signature Square course of the place they’re able to assess the innovation, make inquiries and provides open suggestions to the scientist.
This licensing alternative introduces a modified peptide inhibitor of CDK5/p25 advanced exercise that may deal with cancers (e.g., glioblastoma and colon most cancers) inflicting irregular regulation of central nervous system (CNS) processes. This know-how has demonstrated dramatic will increase in survival in mouse fashions and qualifies for FDA Quick Observe and Orphan Drug Standing in Glioblastoma (GBM).
GBM is essentially the most aggressive type of mind most cancers. The present commonplace of care towards GBM is a mixture of surgical procedure, chemotherapy and radiotherapy. Nevertheless, after commonplace therapy, the most cancers often recurs – emphasizing a necessity for brand new targets and higher options. A promising goal is cyclin-dependent kinase 5 (CDK5), the hyperactivity of which has been proven to have a task in most cancers development.
TP5/TFP5, a small peptide inhibitor towards CDK5, was developed on the Nationwide Institutes of Well being and modified to extend its passage by means of the blood mind barrier. Researchers on the NCI and NINDS demonstrated that TP5 decreases cell viability and will increase programmed cell dying in GBM and CRC cell traces with aberrant CDK5 exercise. TP5 was discovered to impair DNA restore by inhibiting CDK5 and acted additively and synergistically with DNA-damaging brokers (e.g., temozolomide, irinotecan, irradiation) utilized in therapy of GBM and colon carcinoma. TP5 decreased the tumor quantity and elevated the general survival of orthotopic glioblastoma mouse fashions.
This scientific presentation is a chance to license this know-how, or take part in additional collaborative work to reinforce its growth.
The Expertise Analysis Consortium, which performs a task in evaluating new applied sciences comparable to this, consists of organizations comparable to Pfizer, AbbVie, Amgen and Allergan, and plenty of others.
ABOUT ONE MILLION SOLUTIONS IN HEALTH
The objective of One Million Options in Well being is to form well being care by sharing options and, importantly, to speed up the invention, growth and supply of modern cures, therapies and preventative measures for sufferers around the globe.
On this subsequent yr by means of the Hidden GEMS Program, we can be reviewing 100’s of recent options and new scientific discoveries. By partaking scientists, entrepreneurs, buyers, innovators, trade consultants, well being care professionals, and sufferers throughout varied disciplines, and from around the globe, we will make the most of the ability of the web to disrupt issues in a optimistic and transformative approach to speed up the motion of recent options and scientific discoveries from the scientist to the affected person.
We’re on our method in the direction of accelerating high-potential improvements, catalyzing funding and rising consciousness of, and help for, transformative concepts to enhance well being and save lives. By facilitating efforts to make sure organizations can Join, Be taught + Share, Innovate and Collaborate, our imaginative and prescient is to enhance well being care supply, speed up life sciences analysis, and share affected person and consumer-focused concepts and options.
As a not-for-profit, we welcome your participation and are thrilled to have you ever be part of this transformative journey.
ABOUT the TECHNOLOGY EVALUATION CONSORTIUM and the HIDDEN GEMS PROGRAM
By the Hidden GEMS Program, the Expertise Analysis Consortium from One Million Options in Well being is devoted to enhancing and accelerating life sciences R&D and well being care outcomes. The Expertise Analysis Consortium brings collectively life sciences and/or well being care firms and trade distributors or scientists, and different related companions (e.g., authorities and Universities), to guage and validate applied sciences or companies in a collaborative atmosphere.
The mannequin empowers know-how suppliers/scientists and trade end-users to collectively assess a variety of options in an economical method, producing a depth and breadth of outcomes that no firm can obtain alone. Our mission is to triage and streamline new know-how consideration for the trade and to be the place for the trade to conduct their evaluations and validations.
To acquire additional details about licensing or co-development alternatives OR to have One Million Options in Well being assist your Expertise Switch workplace convey extra of your analysis to market by acquiring extra licensing offers through the Hidden GEMS Program, contact:
Daybreak Van Dam, One Million Options in Well being, 416-402-8274, firstname.lastname@example.org
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